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Old 02-24-2011, 10:15 PM
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k9diabetes k9diabetes is offline
Join Date: Mar 2008
Location: Northern California
Posts: 11,299
Default Re: Humulin vs. Novolin N causing lows - anyone else?

I agree that there shouldn't be a significant difference and I've said for years that they are interchangeable even in terms of dosing.

But I've gotten a handful of reports from people transitioning from Novolin to Humulin who are finding that they need to give less units of the Humulin. Strictly anecdotal but in much higher numbers than I would have expected.

So in the name of caution, I would now recommend that the dosage be lowered some... not more than 20%, maybe more like 10% or a unit or two... when making the switch just in case there is a difference.

You never know what might be happening with the manufacturers - Vetsulin has certainly taught us that. These insulins are not much of a profit maker for the drug companies as they are long out of patent - they would much rather be selling Lantus, Levemir, Novalog, etc.

It will be interesting to see how it plays out.