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Old 06-04-2010, 09:22 PM
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Patty Patty is offline
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Default Re: Mini Schnauzer Gretel - Injection problems brewing!

Carolyn,
Back when Peggy's Forbin was having some sneezing, cold type symptoms after switching I'd looked up the ingredients in Humulin N vs. Novolin N (which is what the Relion insulin is). The primary ingredients are the same:

HUMULIN NPH and HUMULIN 30/70
Each vial or cartridge will contain human insulin (recombinant DNA origin) and the following excipients:
m-cresol distilled 1.6 mg/mL,
glycerol,
phenol 0.65 mg/mL,
protamine sulphate,
dibasic sodium phosphate,
zinc oxide,
water for injections.
Hydrochloric acid and/or sodium hydroxide may have been used during manufacture.
http://www.medsafe.govt.nz/Profs/Dat...Humulininj.htm

NOVO NORDISK PROTAPHANEŽ Isophane (NPH) insulin suspension injection 100 IU/ml

Excipients
Glycerol
Disodium phosphate dihydrate
Metacresol
Phenol
Zinc chloride
Protamine sulphate
Sodium hydroxide
Hydrochloric acid
Water for injections
http://www.medsafe.govt.nz/Profs/Dat...taphaneinj.htm

My understanding is that the difference lies in the fact that some of the ingredients are from different sources and the base solutions are made using different processes.

Here's the link to Peggy's thread if you want to read through it. http://k9diabetes.com/forum/showthre...Forbin&page=18

There are dogs that respond differently to one or the other insulin. Kevin's Ozzi peaked earlier on Novolin N. But for the majority of dogs that have switched they can be used interchangeably.

I think the cost savings definitely makes it worth trying

Patty
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