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Old 10-29-2019, 08:03 AM
SamtheCorgi SamtheCorgi is offline
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Join Date: Oct 2019
Posts: 3
Default New Member too - question on changing to NPH

Quote:
Welcome to the forum!

I copied your question to its own thread so folks can answer you directly.

The switchover usually involves a small reduction in units of insulin in each injection. I personally prefer starting NPH at 3/4 of the units of Vetsulin you were giving. Some might even suggest starting closer to the dose...

Most dogs need about the same number of units but it varies from dog to dog.

Natalie

Hi,
Trying to make sure I am understanding all the information. I read that Vetsulin is a DILUTED insulin and Novo N is more concentrated. But 1u of Vetsulin in a 40cc syringe is EQUAL to 2.5u in a 100cc syringe.

when I say EQUAL, that is in VOLUME only correct? not effectiveness. so if I were to be giving 15units of Vetsulin in a 40cc syringe an equal amount of Novolin N in the 100cc syringe would be (15x2.5) 37.5u ?? I think the flaw here in my thinking is that it only applies to Vetsulin and it is equal in VOLUME only. Is there any meaningful conversion of effectivity??? 15u of Vetsulin (40ccsyringe) is generally considered to be as EFFECTIVE as XXu of Novolin N (in the 100ccsyringe)? Make sense what I ask??

So when referencing above:
"The switchover usually involves a small reduction in units of insulin in each injection. I personally prefer starting NPH at 3/4 of the units of Vetsulin you were giving. Some might even suggest starting closer to the dose...

I guess Dana is a big dog. At 33 units, I would start NPH at at least 24-25 units - that's 75% of 33. And then monitor and raise it up as needed. Depending on if you home test, you might be able to start somewhat higher... 28-30. But I wouldn't personally do that without home blood glucose testing and careful monitoring the first couple of days.

Most dogs need about the same number of units but it varies from dog to dog."

I want to clearly understand the correlation. SO, If I were considering changing the 15u of Vetsulin (which wasn't controlling Sam's BG well to begin with) to Novo N what is the units of Novo N in 100syringe?? The specialist I am working with started us off at 7u of Novo N in the 100 syringe. I can understand being conservative, but it seems to do nothing and Sam's glucose is over 500 at times, not even readable on the meter!!! We are generating a curve, but I don't want Sam to suffer such HIGHS and wanting to learn more about what is a safe approach, avoiding hypo but narrowing in on healthier/lower BGs sooner.

So given the dilute vs concentrate and unit of measure difference, "Some might even suggest starting closer to the dose" What does that mean???
Closer to the equivalent volume?? so 1u of vetsulin is 2.5u of NovoN? but then how to account for the "dilute" versus "concentrate" factors between the two!!

Comments welcomed, confused!!! Thanks!!!
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