New study that current macrocyclic lactone canine heartworm preventatives are not working as well as in the past. They believe that the worms are developing resistance.
http://news.vin.com/VINNews.aspx?articleId=28284
The macrocyclic lactone class of drugs in question comprises avermectin drugs (ivermectin and selamectin) and milbemycins (milbemycin oxime and moxidectin). These drugs are found in all commercial heartworm preventives, including: Heartgard (ivermectin), Tri-Heart Plus (ivermectin), Sentinel (milbemycin oxime), Revolution (selamectin), Advantage Multi (moxidectin), ProHeart6 (moxidectin), and Trifexis (milbemycin oxime).
http://news.vin.com/VINNews.aspx?articleId=28284
The macrocyclic lactone class of drugs in question comprises avermectin drugs (ivermectin and selamectin) and milbemycins (milbemycin oxime and moxidectin). These drugs are found in all commercial heartworm preventives, including: Heartgard (ivermectin), Tri-Heart Plus (ivermectin), Sentinel (milbemycin oxime), Revolution (selamectin), Advantage Multi (moxidectin), ProHeart6 (moxidectin), and Trifexis (milbemycin oxime).
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