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  #161  
Old 11-08-2012, 09:02 AM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

Quote:
Originally Posted by Abby's Mom View Post
So Novolin is saying that the insulin will last 6 months in the refrigerator, AND bring to room temperature prior to rolling/mixing.
Just to be clear, I believe Louise said it was a pharmacist and not directly from the Novolin people. Really doubt an in-use vial of Novolin-N would last 6 months, but???

I would be concerned with possible condensation forming on the inside of the vial if brought all the way to room temperature before every use. Especially if we inject room temperature air into the syringe.

It would be interesting how your new vial behaves.
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  #162  
Old 11-08-2012, 09:06 AM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

Louise..

After some research on the internet... guess where it lead me back to ... a posting on this forum, when Walmart was switching from Novolin to Humulin for their Relion brand.

http://www.k9diabetes.com/forum/showthread.php?t=1849

So, I have my answer, it appears that the Novolin, whether refrigerated or not will last up to 42 days, and perhaps refrigerated up to 6 months...

But, on this posting is was also mentioned that because we are mixing and injecting air into the vial, this can be shorten the life of the insulin, once it has been opened. I have been very careful in the amount of air that I am injecting into the bottle, and it seems to me that it is lasting longer. I believe I may have been injecting too much air, and now I inject a little less than what I am drawing out.

I suppose after 30 days we will know how long it truly lasts.

Barb
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Last edited by Abby's Mom; 11-08-2012 at 10:34 AM.
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  #163  
Old 11-08-2012, 09:07 AM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

ooops, Craig. Just saw your posting. I think our posts had crossed.
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  #164  
Old 11-08-2012, 09:58 AM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

The insulin will start breaking down after it's opened and after the needles and air are inserted, so six weeks is probably all you'll get. Room temperature is fine, actually recommended, as long as it's kept in cool place, see bold below:

Patient Information for Novolin® N

NOVOLIN® N (NO-voe-lin)

NPH,

Human Insulin Isophane Suspension Injection

(recombinant DNA origin) 100 units/mL



All Unopened Novolin N:

Keep all unopened Novolin N in the refrigerator between 36° to 46°F (2° to 8°C).
Do not freeze. Do not use Novolin N if it has been frozen.
If refrigeration is not possible, the unopened vial may be kept at room temperature for up to 6 weeks (42 days), as long as it is kept at or below 77°F (25°C).
If refrigeration is not possible, the unopened PenFill cartridge or InnoLet prefilled syringe may be kept at room temperature for up to 14 days, as long as it is kept at or below 86°F (30°C).
Keep unopened Novolin N in the carton to protect from light.


Novolin N in use:

Vials

Keep at room temperature below 77°F (25°C) for up to 6 weeks (42 days).
Keep vials away from direct heat or light.
Throw away an opened vial after 6 weeks (42 days) of use, even if there is insulin left in the vial
.
Unopened vials can be used until the expiration date on the Novolin N label, if the medicine has been stored in a refrigerator
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  #165  
Old 11-08-2012, 11:00 AM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

the question that we all would like to know is it better to refrigerate or not an open vial of insulin

i have refrigerated an open vial from the beginning i dont warm it up her doses are so small and it doesn't bother her we only use it for a month at the most

now would that insulin be better at room temperature and work better than taking it from a cold state to a warm state every time you remove it from the refrigerator common sense may say at least for me that that constant abrupt changes in temperature may affect the quality of the insulin .

it is convenient to keep in the fridge but could it easily be kept in a medicine cabinet

well you got me thinking and that can be dangerous

i may rethink what i am doing and may go without refrigeration when we make the change next month change for me is a bit of a reset

many thoughts on this no specific answers i guess it is so individual just like this disease is for our pups
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  #166  
Old 11-08-2012, 11:31 AM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

Thanks for your input everybody.

Used the new bottle of insulin last night and it remained nice and cloudy after storing it in the refrigerator and did not separate in the vial or syringe. I'll be watching it closely over the next couple of weeks. However, the 2 week old insulin separated while in the refrigerator and after letting it come to room temperature as recommended by clinic pharmacist and rolling it separated again - so bye-bye to that bottle.

The one thing I've learned out of all this about insulin besides the fact that nobody is saying exactly the same thing is:
*WalMart Pharmicist instructions of 28 days unrefrigerated is for humans.
*NovoNordisk rep instructions of 42 days unrefrigerated is for humans.
*Veternarians recommendations for dog/cat patients are different than for humans.
*Dr. Mark Peterson: Refrigerated - 6 mos. but contamination can be issue and many vets recommend switching every 3 mos. or so.
*Munchie's IMS: Refrigerated - 4 to 6 months.
*Clinic Pharmacist: Refrigerated - 6 mos.- but let vial reach room temp. Dr. Peterson says that exposure to light can be an issue which has an effect on insulin so letting it sit out to reach room temp doesn't sound like a good idea to me.

So in the future I'll keep a close eye on the vial every time I need to fill the syringe, hopefully be able to use it for at least a couple of months as opposed to 2 weeks but if it doesn't look right, toss it.

Louise
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  #167  
Old 11-08-2012, 02:26 PM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

Glad you were able to get a new bottle of insulin and I hope Munchie is doing well today.
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  #168  
Old 11-08-2012, 02:40 PM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

keep us posted. I still have Jenny's in the fridge. We replace it every month and have so much left over
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  #169  
Old 11-08-2012, 02:45 PM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

I always stored Buddy's insulin in the fridge. I never warmed the bottle each time but after filling the syringe I would warm it by placing it in my mouth (sideways) for a few minutes to remove the ouch when injecting.

Jenny
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  #170  
Old 11-08-2012, 05:20 PM
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Default Re: Munchie–11 yr. old MiniSchnauzer–Just Diagnosed

Jenny-
Fancy meeting you here. The same old MunchMan - different forum. Could have done without the diabetes!

Judi-
Will definitely keep you posted. I know what you mean - throwing more away than will be used. Hope insulin lasts a little longer this time and soooooo glad WalMart has a reasonable price.

Dawn -
Thanks. Munchie is doing much better today. It took discontinuing the Enalapril....but that's another whole story.

Louise
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Munchie, 11 yr. old Mini-Schnauzer, 23.2 lbs., diabetes 10/24/12. 8 units Novolin N 2xdaily.
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