Diabetes in Dogs: The k9diabetes.com Forum

Go Back   Diabetes in Dogs: The k9diabetes.com Forum > Answers - Archive of helpful posts from the forum > Insulin

Insulin Kinds of insulin, action profiles, use in dogs, where to buy, etc.

Closed Thread
Thread Tools Search this Thread Display Modes
Old 06-11-2009, 11:46 AM
We Hope's Avatar
We Hope We Hope is offline
Founding Moderator
Join Date: Mar 2008
Posts: 2,155
Default Re: Hello! Rolo and I are new here.


What's said when you talk about Lantus vs Levemir is that Levemir has more consistency in both the same patient and from patient to patient than Lantus does.

There's also the way each one does its job. Lantus forms crystals under the skin and after that, they absorb very similarly to the way the rest of the suspended insulins do--by the crystals being absorbed gradually. Levemir's action is to bind to the albumin in the blood to produce its effect, so there's nothing to "break down", if you will, as in Lantus and the suspended insulins.

With Levemir, there's no waiting for any crystals, whether they're in the vial and injected or are formed under it after injection by the reaction between Lantus and the pH of the skin. Levemir's "suspension" takes place in the bloodstream, with the binding to the albumin in the blood.

Some people put the knock on Levemir because it's approved for being used once or twice a day, depending on the patient's needs. Lantus is approved for once daily use. But when you talk with people who use Lantus, it becomes clear that many of them didn't work out with once daily dosing; they're on twice daily split dosing, which would be considered "off label" (nothing wrong about using a drug off label). Have a friend who has been using it twice a day for a long time--once daily didn't work for her.

The big "sell" on Lantus from Sanofi-Aventis has always been once daily dosing. The big "sell" on Ultralente insulin was always that it was once daily dosing. That more often than not didn't work out for the people using it, and they needed to use it twice daily. Both Novo and Lily discontinued their Ultralente insulins in the period between 2003-2005 because neither of them were selling enough of it to keep up production.

I'd believe the Levemir onset is because of its action.

Old 06-14-2009, 07:41 PM
grace.device's Avatar
grace.device grace.device is offline
Join Date: Apr 2009
Posts: 34
Default Re: Hello! Rolo and I are new here.

Good news and bad news from our curve yesterday. I tried thought the green beans had no effect based on the urine test but I was wrong. I left out the evening snack all together yesterday and today and still got a massive spike

0745 - 220 (+ breakfast, 1.0U Levemir, 0.2U NR)
0945 - 157
1145 - 146
1545 - 212
1945 - 398 ( + dinner, 1.0U Levemir, 0.3U NR)
2145 - 306

0745 - 184 ( + breakfast, 1.0U Levemir, 0.15U NR- the drop yesterday was a little much)
0945 - 169
1145 - 121
1745 - 185
1945 - 375 ( + dinner, 1.0U Levemir, 0.3U NR)

Today's numbers were great, and if it weren't for that spike I wouldn't change a thing! Rolo has never had such consistency or such good numbers. Tomorrow I will start giving her dinner at 1745 with her NR, and leaving the Levemir until 1945, so the NR will cover the gap in duration (thank you "Using Insulin" for that trick). Luckily her night dose seems to be giving her adequate duration, judging from her morning fastings.

For now I am just going to keep the doses the same (0.15U NR and 1.0U Levemir), but I am sure I will have to adjust them now that they're not being given at the same time. Since I am going to be giving her evening Levemir at the peak of the NR, I want to make sure she does not get a drop from the NR so the Levemir doens't send her too low. I think the Levemir is what is causing the lowest number at 4-hrs post injection (146 yesterday, 121 today), so she may need a little snack before bed, but we'll see tomorrow.

I'll report back tomorrow with our results!

Old 06-15-2009, 08:57 AM
grace.device's Avatar
grace.device grace.device is offline
Join Date: Apr 2009
Posts: 34
Default Re: Hello! Rolo and I are new here.

I know it will be a bit of a battle getting the NR to cover the gap - it needs to cover her food, and stop a 200 point rise. I will start conservatively tonight with 1/4U NR with dinner at 5:45pm and see where we end up at 7:45 for the Levemir. I don't think I'm going to increse the Levemir dose at all - she's pretty much below 180 most of the time. Plus, 1.0U Levemir keeps her steady all day even starting at 350-400 at 7:30pm, so it may bring her a bit lower when she dose not have that giant spike to contend with.


Last edited by We Hope; 06-19-2009 at 09:30 PM. Reason: removing non-Levemir-related information
Closed Thread

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump

All times are GMT -7. The time now is 03:22 AM.

Disclaimer -- The content on this site is provided for informational and educational purposes only. While we make every effort to present information that is accurate and reliable, the views expressed here are not meant to be a substitute for the advice provided by a licensed veterinarian. Please consult with your veterinarian for specific advice concerning the medical condition or treatment of your pet and before administering any medication or pursuing any course of treatment that you may read about on this site.

The views and opinions expressed by contributors to this forum are strictly their own and do not necessarily reflect the opinions and views of the owners, administrators, or moderators of this forum and the k9diabetes.com website.

Powered by vBulletin® Version 3.8.5
Copyright ©2000 - 2022, Jelsoft Enterprises Ltd.
Copyright 2009, 2010 k9diabetes.com. All rights reserved.