Diabetes in Dogs: The k9diabetes.com Forum

Go Back   Diabetes in Dogs: The k9diabetes.com Forum > Canine Cushings - See http://www.k9cushings.com

Canine Cushings - See http://www.k9cushings.com The new www.K9Cushings.com is open! So this former temporary home is closed to new posts. Please go to www.k9cushings.com and check to see if your membership transferred there. It will remain viewable, however, until the transition to the new forum at http://www.k9cushings.com/forum is complete.

Thread Tools Search this Thread Display Modes
Prev Previous Post   Next Post Next
Old 04-20-2009, 08:51 PM
4Mikeydog's Avatar
4Mikeydog 4Mikeydog is offline
Junior Member
Join Date: Apr 2009
Location: New Jersey
Posts: 10
Default Mikey no longer doing well on Trilostane

I am so glad I found you!! My 8 1/2 year old miniature poodle, Mikey was diagnosed with pituitary dependent cushings last March after an ACTH stim test with results:
pre 4.3 and post 39.7 and an ultrasound.
He had most of the classic symptoms; excessive thirst, excessive urinating, ravenous appetite, weak hindquarters, potbelly, and lethargy. He had a dull coat which had gone from a beautiful apricot color to a pale shade of cream, but no visible hair loss...
Mikey was put on Trilostane 30 mg 1x per day and within 2 weeks most of his symptoms started to subside.
All subsequent ACTH tests show effective management of cortisol. Mikey was his old self for quite awhile
However..after 5 months on Trilostane, my sweet guy began to lose hair at the tops of his ears and on his tail. This hair loss has continued.
Trilostane remained at 30mg 1x per day until some adjustments due to trembling and lethargy.
Mikey is presently on Trilostane 10mg BID. He has continued to lose hair, weight and muscle mass. He has an underlying intestinal or absorption problem which is currently being mediated.
His IM specialist ordered the UTK adrenal panel 3/30/09.
The results are as follows:

Cortisol Pre 8.3 ng/ml Post 48.1 ng/ml

Androstenedione Pre 0.90 ng/ml Post 0.70 ng/ml

Estradiol Pre 85.6 pg/ml Post 82.6 ng/ml

Progesterone Pre 1.00 ng/ml Post 1.70 ng/ml

17 OH Progesrerone Pre 4.89 ng/ml Post 6.77 ng/ml

Aldosterone Pre 21.6 pg/ml Post 37.9 pg/ml

Androstenedione, Estradiol, Progesterone, and 17 OH progesterone are all elevated.
I've read enough to know that Trilostane can do this.
Today we met with the IM specialist who is taking over for his original dr who is out on maternity leave..
I am truly confused and upset.
Clinically all signs of urinating, drinking, and appetite are mediated. However Mikey is lethargic, has lost most of his hair and is down to 12 lbs (poor guy)!
The vet initially recommended increasing the Trilostane
I commented that I thought melatonin,
flaxseed oil with lignans and or a maintenance dose of lysodren may be a better choice.
The specialist said we could do that and suggested 5 mg of melatonin BID first with Trilostane as is..
Then if I wanted to introduce the maintenance dose of Lysodren, I should stop Trilostane for 2 weeks and then start a maintenence dose of Lysodren. I'm very alarmed about this because I don't know if the Trilostane will really be out of his system enough to do this safely...
The IM specialist said that if we wait the 30 days without Trilostane we will have to actually load him instead. My questions are as follows:
What is your experience with this concept?
What have you experienced in switching a dog from one treatment to another?
Do you have any recommendations for how to start treatment with melatonin?
Do you think the 5mg melatonin BID is too high a dose for a 12 lb dog?
I am sorry if I am rambling..but I am truly frantic!

Dorothy and Mikey

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump

All times are GMT -7. The time now is 06:16 AM.

Disclaimer -- The content on this site is provided for informational and educational purposes only. While we make every effort to present information that is accurate and reliable, the views expressed here are not meant to be a substitute for the advice provided by a licensed veterinarian. Please consult with your veterinarian for specific advice concerning the medical condition or treatment of your pet and before administering any medication or pursuing any course of treatment that you may read about on this site.

The views and opinions expressed by contributors to this forum are strictly their own and do not necessarily reflect the opinions and views of the owners, administrators, or moderators of this forum and the k9diabetes.com website.

Powered by vBulletin® Version 3.8.5
Copyright ©2000 - 2021, Jelsoft Enterprises Ltd.
Copyright 2009, 2010 k9diabetes.com. All rights reserved.