Re: Angelina 13.5 year old/13kg Maltese Cross on Trilostane
The varying research recommendations regarding trilostane do seem pretty overwhelming, don't they?? And there certainly has been some evolution along the way. The "Dr. Neiger" who is referenced here conducted some of the very first research that was performed at the Royal Vet College in London, and his study results were among those upon which the first Vetoryl dosing recommendations were based. Many of the recommendations contained in the 2004 paragraph that Patti has cited remain part of Dechra's current Vetoryl dosing protocol. But there are some that have been revised as a consequence of subsequent studies.
For instance, you'll see that the 2004 recommendation was that if the decision was made to shift to twice daily dosing, you actually DOUBLED the daily dose (rather than dividing the once daily dose in half). Since my dog started on trilostane right at that time, that is precisely what we did with him. The recommended once daily dose for his weight was 120 mg., so we added another 120 mg. at night (can you believe we were giving a 70 lb. dog 240 mg.?). Even at that whopping dose, he never had an ACTH "post" result that was less than 6 or 7. (But that is a whole other story...). I absolutely CRINGE now when I think that we were giving him that high of dose. But that was the protocol at the time, and he actually did very well on it for several months.
Anyway, that is one of the reasons why we are trying to track down and document for our members the most recent studies and clinical protocols. Because there have been changes along the way, just is the case with any evolving medical treatment.
Marianne
Originally posted by Patricia ann Wh
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For instance, you'll see that the 2004 recommendation was that if the decision was made to shift to twice daily dosing, you actually DOUBLED the daily dose (rather than dividing the once daily dose in half). Since my dog started on trilostane right at that time, that is precisely what we did with him. The recommended once daily dose for his weight was 120 mg., so we added another 120 mg. at night (can you believe we were giving a 70 lb. dog 240 mg.?). Even at that whopping dose, he never had an ACTH "post" result that was less than 6 or 7. (But that is a whole other story...). I absolutely CRINGE now when I think that we were giving him that high of dose. But that was the protocol at the time, and he actually did very well on it for several months.
Anyway, that is one of the reasons why we are trying to track down and document for our members the most recent studies and clinical protocols. Because there have been changes along the way, just is the case with any evolving medical treatment.
Marianne
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